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Updated: Feb 15, 2026

Intraoperative Ultrasound in Spinal Surgery
Published on: August 17, 2022
Intraoperative intravenous fluorescein as an adjunct during surgery for peroneal intraneural ganglion cysts
Jonathan J Stone1, Christopher S Graffeo1, Godard C W de Ruiter2
1Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Abstract:
The intraoperative use of intravenous fluorescein is presented in a case of peroneal intraneural ganglion cyst. When illuminated with the operative microscope and yellow filter, this fluorophore provided excellent visualization of the abnormal cystic peroneal nerve and its articular branch connection. The articular (synovial) theory for the pathogenesis of intraneural cysts is further supported by this pattern of fluorescence. Further, our report presents a novel use of fluorescein in peripheral nerve surgery.
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