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Stereotactic Volume Modulated Arc Radiotherapy in Canine Meningiomas: Imaging-Based and Clinical Neurological

Mario Dolera1, Luca Malfassi1, Simone Pavesi1

  • 1From the La Cittadina Fondazione Studi e Ricerche Veterinarie, Romanengo, Italy (M.D., L.M., S.P., S.M., M.S., G.M., N.C., S.F.); and Azienda Ospedaliera della Provincia di Lodi, Lodi, Italy (G.U.).

Journal of the American Animal Hospital Association
|January 27, 2018
PubMed

Insights

High-dose hypofractionated volumetric modulated arc radiotherapy shows feasibility and efficacy in treating canine meningiomas. This advanced radiation technique achieved significant tumor response and survival rates with minimal side effects in dogs.

Area of Science:

  • Veterinary Neurology
  • Radiation Oncology
  • Comparative Oncology

Background:

  • Canine meningiomas are common primary brain tumors in dogs.
  • Current treatment options for canine meningiomas have limitations.
  • Advanced radiotherapy techniques offer potential for improved outcomes.

Purpose of the Study:

  • To assess the feasibility and efficacy of high-dose hypofractionated volumetric modulated arc radiotherapy (VMAT) for canine meningiomas.
  • To evaluate treatment response and survival rates in dogs with encephalic and spinal meningiomas.
  • To determine the incidence and severity of radiotoxic effects associated with this treatment modality.

Main Methods:

  • Prospective study involving 39 dogs with presumed meningiomas based on MRI.
  • Treatment administered: high-dose hypofractionated VMAT (33 Gy in five fractions) using a linear accelerator.
  • Feasibility assessed by planned vs. delivered dose checks; efficacy evaluated through clinical examinations and serial MRI scans.
  • Response assessment based on volumetric disease reduction and clinical neurological status.

Main Results:

  • Complete and partial responses observed in 65.5% of surviving dogs at 24 months.
  • Two-year overall survival rate was 74.3%, with a 97.4% disease-specific survival rate.
  • Adverse events were infrequent and mild, indicating good tolerability.

Conclusions:

  • High-dose hypofractionated VMAT is a feasible and effective treatment for canine meningiomas.
  • This radiotherapy approach offers promising long-term tumor control and survival benefits.
  • The treatment is well-tolerated with a low incidence of significant side effects in canine patients.

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