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Related Experiment Video

Updated: Feb 15, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
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Quantitative microstructural cerebral changes in neurofibromatosis type 1.

Eva Bültmann1, Loukia M Spineli2, Hans Hartmann3

  • 1Institute of Diagnostic and Interventional Neuroradiology, Hannover Medical School, Hannover, Germany.

Brain & Development
|January 27, 2018
PubMed
Summary

Neurofibromatosis type 1 (NF1) in children shows measurable brain microstructural differences using T2 relaxation times. These changes were detected in multiple brain regions compared to healthy children.

Keywords:
BrainChildrenMagnetic resonance imagingNeurofibromatosis type 1Quantitative imagingT2 relaxation time

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Area of Science:

  • Neuroimaging
  • Pediatric Neurology
  • Genetics

Background:

  • Neurofibromatosis type 1 (NF1) is a genetic disorder.
  • Cerebral microstructural changes can occur in NF1 patients.
  • T2 relaxation time measurements offer insights into brain tissue properties.

Purpose of the Study:

  • To evaluate microstructural cerebral changes in children with NF1.
  • To utilize T2 relaxation time measurements at 3 Tesla for this evaluation.
  • To compare NF1 patients with healthy controls.

Main Methods:

  • Retrospective analysis of 19 pediatric NF1 patients and 44 healthy children.
  • 3 Tesla MRI examinations with triple echo TSE sequence for T2 mapping.
  • Measurement of T2 relaxation times in 37 distinct brain regions.

Main Results:

  • T2 relaxation times tended to increase in NF1 patients compared to controls (1.01% to 11.85%).
  • Reduced T2 values were observed in the posterior limb of the internal capsule and parietooccipital white matter.
  • No significant differences were found between hemispheres or based on optic glioma or neuropsychological status.

Conclusions:

  • T2 relaxation time measurements can identify microstructural brain differences in NF1 patients.
  • These measurable differences exist regardless of visible abnormalities on conventional MRI.
  • T2 mapping provides a sensitive tool for characterizing brain changes in pediatric NF1.