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Meningococcal meningitis with neurological complications and meningococcemia due to serogroup W sequence type 11

Nobuaki Mori1, Tomofumi Hayashi1, Hideki Nakamura1

  • 1Department of General Internal Medicine, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan.

Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy
|January 27, 2018
PubMed

Insights

The first reported case of invasive meningococcal disease (IMD) in Japan caused by the emerging MenW strain highlights its potential for severe neurological complications and reactive arthritis.

Area of Science:

  • Infectious Diseases
  • Neurology
  • Microbiology

Background:

  • Invasive meningococcal disease (IMD) caused by Neisseria meningitidis serogroup W (MenW) sequence type-11 complex has emerged globally.
  • This strain is associated with high mortality and unusual clinical presentations.
  • IMD incidence is typically low in Japan, with MenW being rare.

Observation:

  • A previously healthy 27-year-old Japanese woman presented with meningococcal meningitis and meningococcemia.
  • The patient experienced neurological complications including abducens palsy, cerebellitis, and cerebellar infarction.
  • Reactive arthritis was also observed as a complication.

Findings:

  • This case represents the first documented instance of this specific MenW strain causing IMD in Japan.
  • The patient's presentation included severe neurological sequelae and reactive arthritis.
  • The clinical course underscores the atypical manifestations associated with this emerging strain.

Implications:

  • This case highlights the potential for global spread of virulent IMD strains into new regions.
  • It provides critical insights into the diverse and severe complications, particularly neurological, that can arise from MenW infections.
  • Understanding these complications is crucial for early diagnosis and management of IMD, even in low-incidence areas.
Keywords:
CerebellitisMeningococcal meningitisMeningococcemiaSequence type-11 complexSerogroup W

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