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Related Experiment Videos

Alfentanil for short duration laparoscopic procedures.

K S Lee, G J Purcell, B R Rae

    Anaesthesia and Intensive Care
    |February 1, 1986
    PubMed
    Summary
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    Low-dose alfentanil (8 micrograms kg-1) effectively managed pain during short surgeries. This analgesic reduced sympathetic responses to intubation, ensuring patient safety without compromising recovery.

    Area of Science:

    • Anesthesiology
    • Pharmacology

    Background:

    • Intubation can trigger significant cardiovascular responses.
    • Effective analgesia is crucial for managing these responses during short surgical procedures.

    Purpose of the Study:

    • To evaluate the efficacy and safety of low-dose alfentanil as an analgesic for short-duration surgery.
    • To assess alfentanil's impact on cardiovascular responses to intubation.

    Main Methods:

    • A double-blind study involving 41 women undergoing laparoscopy.
    • Participants received either alfentanil (8 micrograms kg-1) or normal saline at induction.
    • Standard anesthetic agents (thiopentone, alcuronium, enflurane, nitrous oxide, oxygen) were administered to all patients.

    Main Results:

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    • Alfentanil did not significantly alter mean arterial pressure (MAP) post-induction.
    • MAP remained stable after intubation with alfentanil, unlike a significant rise in the saline group (P < 0.001).
    • Alfentanil resulted in a smaller pulse rate increase post-intubation compared to saline (P < 0.001).

    Conclusions:

    • Low-dose alfentanil is a safe and effective analgesic for short surgeries.
    • Alfentanil mitigates sympathetic responses to intubation without causing cardiovascular depression.
    • Postoperative recovery was not compromised in patients receiving alfentanil.