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Updated: Feb 15, 2026

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue
Published on: May 1, 2019
Autoimmunity and Gastric Cancer
Nicola Bizzaro1, Antonio Antico2, Danilo Villalta3
1Laboratorio di Patologia Clinica, Azienda Sanitaria Universitaria Integrata, 33100 Udine, Italy. nic.bizzaro@gmail.com.
Abstract:
Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid. Here, we review the association of autoimmune gastritis with gastric cancer and other autoimmune features present in gastric neoplasms.
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