Related Experiment Video
Updated: Feb 15, 2026
Outer-Boundary Assisted Segmentation and Quantification of Trabecular Bones by an Imagej Plugin
Published on: March 14, 2018
Trabecular Bone Score in Obese and Nonobese Subjects With Primary Hyperparathyroidism Before and After
Yu-Kwang Donovan Tay1,2,3, Natalie E Cusano1, Mishaela R Rubin1
1Department of Medicine, Division of Endocrinology, College of Physicians & Surgeons, Columbia University, New York, New York.
Context:
Obesity has been shown to be unfavorable to skeletal microarchitecture when assessed by trabecular bone score (TBS). The influence of adiposity on skeletal microstructure in primary hyperparathyroidism (PHPT) has not yet been evaluated.
Objective:
To investigate the effect of obesity on TBS and bone mineral density (BMD) in subjects with PHPT at baseline and through 2 years after parathyroidectomy.
Design:
Prospective observational study.
Setting:
Referral center.
Patients Or Other Participants:
Thirty men and women with PHPT undergoing parathyroid surgery.
Main Outcome Measures:
TBS and BMD by dual-energy X-ray absorptiometry (DXA).
Results:
There were notable improvements in lumbar spine and femoral neck BMD in the obese (lumbar spine: 4.3 ± 4.7%, femoral neck: 3.8 ± 6.6%; P < 0.05 for both) and nonobese subjects (lumbar spine: 3.8 ± 5.6%, femoral neck 3.1 ± 5.0%; P < 0.05 for both) but no marked change in TBS in either group at 24 months postparathyroidectomy. Obese subjects had fully degraded TBS values compared with the nonobese subjects, whose TBS values were minimally below normal throughout the study (baseline: 1.199 ± 0.086 vs 1.327 ± 0.099, respectively; P = 0.003; 24 months: 1.181 ± 0.061 vs 1.352 ± 0.114, respectively; P = 0.001), despite improvements in BMD.
Conclusions:
The detrimental effect of obesity on TBS, an index of bone quality, was demonstrated in subjects with PHPT. Obesity was associated with fully degraded skeletal microarchitecture as measured by TBS in PHPT, despite similar values in bone density by DXA compared with nonobese subjects. TBS values did not improve postparathyroidectomy in either obese or nonobese subjects.
More Related Videos
Related Concept Videos
01:24Obesity
01:06Introduction to z Scores
z scores...
01:05Introduction to z Scores
z scores...
01:17z Scores and Area Under the Curve
01:07z Scores and Unusual Values
This score indicates how far a value is from the mean in terms of standard deviation. For example, if a data value has a z score of +1, the researcher can infer that the particular data value is one standard deviation above the mean. If another data...
01:13Cable Subjected to Its Own Weight
A generalized loading function is employed to analyze a cable subjected to its own weight. This function considers the force acting along the cable's arc length rather than its projected length, providing a more accurate...