Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pancytopenia caused by iron-dextran.

H Hurvitz, E Kerem, E Gross-Kieselstein

    Archives of Disease in Childhood
    |February 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Value of Routine Pelvic Examination in the Follow-Up of Patients Receiving Adjuvant Radiation Therapy for Endometrial Cancer: An Australian Tertiary-Centre Experience.

    Journal of medical imaging and radiation oncology·2025
    Same author

    Epithelial RANKL Limits Experimental Periodontitis via Langerhans Cells.

    Journal of dental research·2024
    Same author

    Medical graphics to improve patient understanding and anxiety in elderly and cognitively impaired patients scheduled for transcatheter aortic valve implantation (TAVI).

    Clinical research in cardiology : official journal of the German Cardiac Society·2023
    Same author

    Informed Consent before coronary angiography and percutaneous coronary intervention from the patient's perspective: A picture is worth a thousand words.

    International journal of cardiology. Heart & vasculature·2022
    Same author

    Review of indications for immunoglobulin (IG) use: Narrowing the gap between supply and demand.

    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine·2020
    Same author

    A nurse- and peer-led psycho-educational intervention to support women with gynaecological cancers receiving curative radiotherapy: The PeNTAGOn randomised controlled trial - ANZGOG 1102.

    Gynecologic oncology·2020
    Same journal

    Protecting adolescent confidentiality in the digital age: a global call for adolescent-informed electronic health records.

    Archives of disease in childhood·2026
    Same journal

    Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study.

    Archives of disease in childhood·2026
    Same journal

    Artificial intelligence for child health: current capabilities and the next frontier.

    Archives of disease in childhood·2026
    Same journal

    Troubled origins and lasting impact of the first insulin injection.

    Archives of disease in childhood·2026
    Same journal

    Paediatric readiness assessment tools in emergency care: a scoping review.

    Archives of disease in childhood·2026
    Same journal

    Building a paediatric workforce to deliver the NHS prevention agenda: time for paediatric public health medicine?

    Archives of disease in childhood·2026
    See all related articles

    An infant with Down syndrome developed pancytopenia after receiving intramuscular iron-dextran. This severe reaction, potentially allergic, recurred upon re-exposure and is a previously unreported side effect.

    Area of Science:

    • Hematology
    • Immunology
    • Pediatrics

    Background:

    • Intramuscular iron-dextran is used to treat iron deficiency anemia.
    • Down syndrome can present with complex medical conditions requiring careful treatment considerations.

    Observation:

    • An infant diagnosed with Down syndrome experienced pancytopenia, a condition characterized by a deficiency of all blood cell types.
    • The pancytopenia developed following administration of intramuscular iron-dextran.
    • Hematological abnormalities reappeared during subsequent iron-dextran challenges.

    Findings:

    • Positive migration inhibiting factor tests suggest a cell-mediated immune response.
    • Mast cell degranulation tests indicate an allergic reaction.
    • The findings support an allergic pathogenesis for the observed pancytopenia.

    Related Experiment Videos

    Implications:

    • This case highlights a previously unreported adverse reaction to intramuscular iron-dextran.
    • Clinicians should consider the potential for allergic reactions, particularly in infants with Down syndrome.
    • Further investigation into the immunological mechanisms of iron-dextran adverse events is warranted.