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The Sister Study Cohort: Baseline Methods and Participant Characteristics
Dale P Sandler1, M Elizabeth Hodgson2, Sandra L Deming-Halverson2
1Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.
Environmental Health Perspectives
|January 27, 2018
Summary
The Sister Study enrolled over 50,000 women with a family history of breast cancer to investigate environmental and genetic risk factors. This large, diverse cohort provides valuable data for understanding breast cancer etiology and other health outcomes.
Area of Science:
- Environmental health
- Epidemiology
- Genetics
Background:
- The Sister Study addresses knowledge gaps in breast cancer research, particularly concerning environmental and genetic exposures.
- It leverages the higher incidence of breast cancer in women with a sister diagnosed with the disease.
Purpose of the Study:
- To recruit a large, diverse cohort of women with a sister diagnosed with breast cancer.
- To collect comprehensive data on environmental exposures, genetic factors, and lifestyle to identify breast cancer risk factors.
Main Methods:
- Recruited 50,884 women aged 35-74 in the U.S. and Puerto Rico.
- Employed novel strategies to ensure diversity in race/ethnicity, education, and income.
- Collected biological samples and extensive data on potential breast cancer risk factors.
Main Results:
- The cohort is diverse, including significant numbers of women from underrepresented groups.
- Most participants were postmenopausal, parous, never-smokers, and had a BMI <29.9 kg/m².
- 16.5% of participants had average or lower breast cancer risk based on the Gail score.
Conclusions:
- The Sister Study is a unique resource for investigating environmental and genetic breast cancer risk factors.
- Extensive life-course exposure data and baseline specimens offer significant opportunities for research.
- Collaborations are encouraged to maximize the study's potential for advancing breast cancer research and understanding other women's health outcomes.
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