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Protein binders and their applications in developmental biology
Stefan Harmansa1, Markus Affolter2
1Growth and Development, Biozentrum, University of Basel, 4056 Basel, Switzerland.
Development (Cambridge, England)
|January 28, 2018
Summary
New protein binders offer precise control over protein function in living organisms. These tools, including nanobodies and DARPins, are advancing developmental and synthetic biology research.
Area of Science:
- Developmental biology
- Synthetic biology
- Molecular biology
Background:
- Precise spatial and temporal regulation of protein function in vivo is crucial for advancing developmental biology.
- Functionalized protein binders are emerging as powerful tools for targeting and manipulating proteins within living systems.
Purpose of the Study:
- To provide an overview of currently available protein binders.
- To highlight recent advancements in applying protein binder-based tools in developmental and synthetic biology.
Main Methods:
- Review of literature on protein binder scaffolds (e.g., nanobodies, DARPins, monobodies).
- Analysis of applications in manipulating protein function in living cells.
Main Results:
- Protein binders offer versatile strategies for blocking or perturbing protein function.
- These tools enable systematic, spatial, and temporal regulation of protein activity.
Conclusions:
- Protein binder technology is a rapidly advancing field with significant implications for biological research.
- Further development and application of these tools will accelerate progress in developmental and synthetic biology.
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