The role of immunoglobulin E receptors in allergic diseases

Recent studies presented evidence that subpopulations of lymphocytes, monocytes and eosinophils carry immunoglobulin (IgE)-specific membrane receptors which differ from the classical Fc epsilon-receptors on basophil granulocytes and mast cells. The analysis of IgE-receptor interactions with various cells has led to important insights as to the requirements of IgE-antibody regulations. In addition, the membrane biochemical mechanisms in the induction of mediator release became better understood. The expression of low affinity receptors on lymphocytes appears to by intimately involved in the generation of IgE enhancing and suppressive factors. In future, these molecules might be available for immunotherapy. A summary of the recent knowledge combined with our data is presented.