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[Thyroid dysfunction in patients with small intestinal bacterial overgrowth]
Paulina Konrad1, Jan Chojnacki1, Aleksandra Kaczka1
1Medical University of Łodz, Poland: Department of Clinical Nutrise and Gastroentorological Diagnostics.
Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 28, 2018
Summary
Small intestinal bacterial overgrowth (SIBO) is linked to thyroid dysfunction, particularly in constipation-predominant SIBO. This suggests thyroid function should be considered in SIBO diagnosis and treatment.
Area of Science:
- Gastroenterology
- Endocrinology
Background:
- Small intestinal bacterial overgrowth (SIBO) and thyroid diseases share symptoms like altered bowel habits.
- The potential causal relationship between SIBO and thyroid disorders remains unclear.
Purpose of the Study:
- To investigate thyroid function indices in patients with different clinical presentations of SIBO.
- To assess potential correlations between SIBO and thyroid health.
Main Methods:
- Studied 34 diarrhea-predominant SIBO patients, 30 constipation-predominant SIBO patients, and 30 controls.
- SIBO diagnosed using lactulose hydrogen breath test (LHBT).
- Measured serum TSH, FT3, FT4, and anti-thyroid peroxidase (ATPO) antibodies.
Main Results:
- SIBO patients exhibited significantly elevated LHBT values compared to controls.
- Constipation-predominant SIBO patients showed altered FT3, FT4, and TSH levels compared to controls.
- Both SIBO groups had significantly higher ATPO antibody levels than controls, indicating autoimmune thyroid activity.
Conclusions:
- Thyroid function may be compromised in individuals with SIBO.
- These findings highlight the importance of evaluating thyroid function in SIBO patients for comprehensive management.
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