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Related Concept Videos

Self-Presentation01:25

Self-Presentation

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Self-presentation is a fundamental aspect of social interaction, shaping both how others perceive individuals and how they view themselves. This dynamic process influences behaviors in various social settings, often leading people to adjust their appearance, speech, and demeanor to align with their desired identity. While self-presentation can be deliberate or unconscious, it plays a critical role in interpersonal relationships and self-perception.Forms of Self-PresentationSelf-presentation can...
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Strategies of Self-Presentation I: Strategic Self-Presentation01:12

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Strategic self-presentation refers to individuals' intentional efforts to influence how others perceive them. This process is employed in various social and professional settings, such as job interviews, dating, politics, and legal contexts, where individuals seek to shape impressions to gain social or material advantages. While people generally present themselves in ways that align with their authentic characteristics, external factors, such as cognitive load, can hinder their ability to...
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Processes of Self-Presentation01:29

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Effective self-presentation is a central component of social interaction and identity construction. It relies on the dynamic processes of defining the situation and engaging in self-disclosure. These mechanisms help individuals navigate social context expectations and manage how others perceive them, fostering mutual understanding and relationship development.Defining the SituationSocial situations are shaped by collectively understood frames—a set of widely understood rules or...
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Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

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Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
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Self-Presentation: Self-Monitoring and Self-Handicapping02:05

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People can go to great lengths to protect their self-image and present themselves in ways that they want others to see them. Sociologist Erving Goffman presented the idea that a person is like an actor on a stage. Calling his theory dramaturgy, Goffman believed that we use “impression management” to present ourselves to others as we hope to be perceived. Each situation is a new scene, and individuals perform different roles depending on who is present (Goffman, 1959). Think about...
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Peptide Bonds02:43

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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...
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Updated: Feb 8, 2026

Immunopeptidomics: Isolation of Mouse and Human MHC Class I- and II-Associated Peptides for Mass Spectrometry Analysis
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Antigen Presentation: Visualizing the MHC Class I Peptide-Loading Bottleneck.

Meindert Lamers1, Ilana Berlin1, Jacques Neefjes1

  • 1Department of Chemical Immunology, Leiden University Medical Center LUMC, 2300 RC Leiden, The Netherlands.

Current Biology : CB
|January 28, 2018
PubMed
Summary
This summary is machine-generated.

The peptide-loading complex, crucial for antigen presentation, has had its entire structure revealed. This breakthrough explains how major histocompatibility complex (MHC) class I molecules acquire antigens.

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Area of Science:

  • Immunology
  • Structural Biology
  • Molecular Biology

Background:

  • Antigen presentation is vital for adaptive immunity.
  • Major histocompatibility complex (MHC) class I molecules present intracellular antigens to T cells.
  • The peptide-loading complex (PLC) facilitates antigen loading onto MHC class I molecules and is a known bottleneck.

Purpose of the Study:

  • To elucidate the structural basis of the peptide-loading complex's function.
  • To understand the mechanism of antigen acquisition by MHC class I molecules.

Main Methods:

  • High-resolution cryo-electron microscopy (cryo-EM) was used to determine the structure of the entire peptide-loading complex.
  • Structural analysis of the 7.2 Å structure.

Main Results:

  • The complete 7.2 Å structure of the peptide-loading complex was determined.
  • Individual component structures were contextualized within the entire complex.
  • The structure provides insights into the mechanism of antigen acquisition.

Conclusions:

  • The determined structure of the peptide-loading complex provides a functional context for its components.
  • This structural insight is a significant advancement in understanding antigen presentation by MHC class I molecules.