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Does the use of melatonin overcome drug resistance in cancer chemotherapy?

Mohammad Hossein Asghari1, Emad Ghobadi2, Milad Moloudizargari3

  • 1Department of Pharmacology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.

Life Sciences
|January 29, 2018
PubMed

Insights

Melatonin enhances cancer therapy by overcoming drug resistance through multiple cellular mechanisms. This compound improves chemotherapy and radiotherapy efficacy in various cancers, including breast, lung, and leukemia.

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Background:

  • Melatonin's role in cancer therapy is increasingly recognized.
  • Cancer cells develop resistance to treatments like chemotherapy and radiotherapy.
  • Melatonin exhibits pleiotropic effects impacting carcinogenesis, tumor growth, and metastasis.

Purpose of the Study:

  • To review the multifaceted effects of melatonin in cancer treatment.
  • To explore how melatonin can overcome drug resistance in various cancers.
  • To highlight melatonin's potential to enhance conventional cancer therapies.

Main Methods:

  • Review of existing studies on melatonin and cancer.
  • Analysis of melatonin's impact on cancer cell signaling pathways.
  • Investigation of melatonin's influence on drug metabolism and DNA repair.

Main Results:

  • Melatonin enhances chemo/radiotherapy efficacy across multiple cancer types.
  • It sensitizes resistant cancer cells by modulating drug targets and reducing drug clearance.
  • Melatonin influences DNA repair, telomerase activity, apoptosis, and autophagy.

Conclusions:

  • Melatonin effectively combats cancer drug resistance through various mechanisms.
  • It modulates key signaling pathways (Akt, MAPK) independently of its antioxidant properties.
  • Melatonin holds significant potential for improving treatment outcomes in breast, lung, hepatic, colon cancers, and leukemia.
Keywords:
CancerChemotherapyDrug resistanceMelatonin

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