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Recent Advances in Bronchopulmonary Dysplasia: Pathophysiology, Prevention, and Treatment

Jung S Hwang1, Virender K Rehan2

  • 1Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, David Geffen School of Medicine at UCLA, 1124 West Carson Street, Torrance, CA, 90502, USA.

Lung
|January 29, 2018
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a severe condition in premature infants affecting multiple organs. Recent research advances understanding of its causes, outcomes, and treatments, aiding clinical care and future studies.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Developmental Neuroscience

Background:

  • Bronchopulmonary dysplasia (BPD) is a major cause of chronic respiratory morbidity in premature infants.
  • Longstanding consequences affect pulmonary function and neurodevelopmental outcomes.
  • Understanding BPD's multifaceted impact is crucial for improving infant health.

Purpose of the Study:

  • To review recent advancements in understanding BPD pathophysiology, prognosis, prevention, and treatment.
  • To summarize progress in the last decade.
  • To guide clinical practice and future research.

Main Methods:

  • Comprehensive review of recent scientific literature on BPD.
  • Analysis of studies on pathobiology, genomics, and clinical outcomes.
  • Synthesis of findings on ventilatory strategies and therapeutic interventions.

Main Results:

  • Significant progress in elucidating BPD pathobiology and genetic factors.
  • Evaluation of evolving ventilatory strategies and their impact on outcomes.
  • Identification of promising therapeutic interventions for BPD prevention and management.

Conclusions:

  • Recent research has deepened the understanding of BPD.
  • This knowledge can improve the care of premature infants at risk for BPD.
  • Further research is essential to continue advancing BPD management and outcomes.

Keywords:
Bronchopulmonary dysplasiaChronic lung disease of prematurityLung injuryPPARγ

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