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An Aptamer-based Sensor for Unchelated GadoliniumIII
Published on: January 9, 2017
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Dentate nucleus T1 hyperintensity: is it always gadolinium all that glitters?
Luca Pasquini1,2, Maria Camilla Rossi Espagnet3,4, Antonio Napolitano5
1Neuroradiology Unit, Imaging Department, Bambino Gesù Children's Hospital, Rome, Italy. lucapasquini3@gmail.com.
La Radiologia Medica
|January 29, 2018
Summary
Gadolinium-based contrast agents (GBCAs) can cause T1-weighted magnetic resonance imaging signal changes in the brain. This case report details a patient with b-cell acute lymphoblastic leukemia (bALL) who experienced these changes after macrocyclic GBCA exposure.
Area of Science:
- Radiology
- Neuroimaging
- Oncology
Background:
- Multiple administrations of gadolinium-based contrast agents (GBCAs) have been linked to T1-weighted magnetic resonance (MR) signal intensity changes.
- Previous studies, including animal and post-mortem human research, have confirmed gadolinium deposition in the brain, particularly in patients with normal renal function.
Observation:
- This communication reports a case of a 15-year-old patient diagnosed with b-cell acute lymphoblastic leukemia (bALL).
- The patient exhibited a hyperintense signal in the dentate nuclei on pre-contrast T1-weighted images after receiving multiple doses of a macrocyclic GBCA.
Findings:
- The observed radiological finding is consistent with gadolinium deposition in the brain.
- Differential diagnoses include iron or manganese accumulation and post-irradiation changes.
Implications:
- Accurate clinical data is crucial for differentiating GBCA-related gadolinium deposition from other causes.
- This case highlights the importance of considering GBCA exposure when interpreting neuroimaging findings in patients, even with macrocyclic agents.
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