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Fibrinolytic Deficit and Platelet Activation in Atrial Fibrillation and Their Postablation Modulation

Abigail Otto1, Jawed Fareed2, Jeffrey Liles1

  • 11 Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|January 30, 2018
PubMed

Insights

Atrial fibrillation (AF) is linked to higher levels of CD40 ligand (CD40-L) and plasminogen activator inhibitor 1 (PAI-1). Catheter ablation significantly reduces these inflammation markers in AF patients.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarker Research

Background:

  • Atrial fibrillation (AF) is associated with inflammatory processes.
  • Cellular mediators like plasminogen activator inhibitor 1 (PAI-1) and CD40 ligand (CD40-L) are implicated in cardiovascular disease pathogenesis.

Purpose of the Study:

  • To investigate the impact of AF on PAI-1 and CD40-L expression.
  • To evaluate the effect of catheter ablation on these biomarkers in AF patients.

Main Methods:

  • Prospective study design.
  • Plasma samples collected from AF patients at baseline and 1, 3 months post-catheter ablation.
  • Comparison with a control group.

Main Results:

  • Significantly elevated baseline CD40-L in AF patients compared to controls (P = .0034).
  • Significant reduction in CD40-L levels at 1 and 3 months post-ablation (P < .0001).
  • Elevated baseline PAI-1 levels in AF patients (19.55 ± 2.17 ng/mL vs 4.85 ± 0.41 ng/mL).
  • Significant decrease in PAI-1 levels 1 month post-ablation (P = .05).

Conclusions:

  • Inflammation plays a key role in AF pathogenesis.
  • Catheter ablation effectively modulates PAI-1 and CD40-L levels, suggesting a therapeutic impact on AF-related inflammation.

Keywords:
AFibablationatrial fibrillationfibrinolysisfibrinolytic deficitplatelet

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