Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

111.6K
Overview
111.6K
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

8.1K
Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
8.1K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

11.9K
The Upf proteins that carry out nonsense-mediated decay (NMD) are found in all eukaryotic organisms, including humans. Each protein has an individual role, but they need to work in collaboration. Upf1 is an ATP-dependent RNA helicase that unwinds the RNA helix. Because Upf1 can unwind any RNA, Upf2 and Upf3 are required to help Upf1 discriminate between nonsense and normal mRNAs.
Usually, Upf3 binds to an Exon Junction Complex (EJC) at mRNA splice sites. If a ribosome fully translates the mRNA,...
11.9K
Nonsense-mediated mRNA Decay02:27

Nonsense-mediated mRNA Decay

3.4K
3.4K
Carrier-Mediated Transport01:06

Carrier-Mediated Transport

1.3K
Carrier-mediated transport is a pivotal process in drug absorption, particularly for lipid-insoluble drugs, and encompasses facilitated diffusion and active transport. Facilitated diffusion allows drugs to move along their concentration gradient without energy expenditure, while active transport utilizes ATP to drive drug movement against this gradient.
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
1.3K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.4K
Overview
84.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Determinants of Delayed Recovery of Consciousness After Analgosedation Discontinuation in the ICU: Insights From Patients With COVID-19 Hypoxemic Respiratory Failure.

Critical care medicine·2026
Same author

A chat with Hippocrates: the oath in the age of artificial intelligence.

Academic medicine : journal of the Association of American Medical Colleges·2026
Same author

Curious Engagement: Navigating False Predicates in Ethics Consultation.

The Journal of clinical ethics·2026
Same author

Forty Years in the Making: From Nihilism Towards a Therapeutic Neuroethics for Disorders of Consciousness.

The Journal of head trauma rehabilitation·2025
Same author

Wisdom in the Public Sphere: Nancy Neveloff Dubler and the New York State Task Force on Life and the Law.

The Journal of clinical ethics·2025
Same author

How to Fix Clinical Ethics Fellowships: Addressing Our Research Imperative.

The American journal of bioethics : AJOB·2025

Related Experiment Video

Updated: Feb 15, 2026

Monitoring Stub1-Mediated Pexophagy
08:26

Monitoring Stub1-Mediated Pexophagy

Published on: May 12, 2023

2.1K

Mediative Fluency and Futility Disputes.

Samantha F Knowlton, Joseph J Fins

    Perspectives in Biology and Medicine
    |January 30, 2018
    PubMed
    Summary

    Resolving medical futility disputes requires open communication, not rigid definitions. Engaging clinicians, patients, and families in dialogue fosters understanding and repairs relationships, improving healthcare equity.

    Area of Science:

    • Medical Ethics
    • Clinical Communication
    • Healthcare Disparities

    Background:

    • Futility disputes in healthcare arise from differing perspectives on treatment appropriateness.
    • Unresolved disputes can lead to relational breaches between clinicians, patients, and families.
    • Existing approaches may exacerbate power imbalances and health disparities.

    Purpose of the Study:

    • To advocate for mediative fluency as a superior approach to resolving medical futility disputes.
    • To highlight the limitations and negative consequences of preemptively applying futility definitions.
    • To promote dialogue that enhances mutual understanding in end-of-life care discussions.

    Main Methods:

    • Conceptual analysis of communication strategies in medical futility disputes.

    More Related Videos

    Electroporation-mediated RNA Interference Method in Odonata
    13:28

    Electroporation-mediated RNA Interference Method in Odonata

    Published on: February 6, 2021

    6.3K
    Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay
    05:21

    Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

    Published on: September 13, 2024

    923

    Related Experiment Videos

    Last Updated: Feb 15, 2026

    Monitoring Stub1-Mediated Pexophagy
    08:26

    Monitoring Stub1-Mediated Pexophagy

    Published on: May 12, 2023

    2.1K
    Electroporation-mediated RNA Interference Method in Odonata
    13:28

    Electroporation-mediated RNA Interference Method in Odonata

    Published on: February 6, 2021

    6.3K
    Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay
    05:21

    Author Spotlight: Optimizing Antibody-Based Cancer Treatments via Antibody-Dependent, Cell-Mediated Cytotoxicity Assay

    Published on: September 13, 2024

    923
  • Critique of the unilateral application of futility definitions.
  • Argument for a dialogic process involving clinicians, patients, and families.

    • Main Results:

    • Preemptive futility definitions stifle crucial conversations and worsen power imbalances.
    • Dialogue allows clinicians to understand patient/family motivations for requesting potentially futile care.
    • Patients and families gain a better understanding of therapeutic limitations through shared knowledge.

    Conclusions:

    • Mediative fluency, emphasizing communication, is essential for resolving futility disputes.
    • Relying on futility definitions is often ineffective and can be detrimental.
    • Open dialogue promotes shared understanding, respects values, and can repair relational breaches in complex medical situations.