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The Association between Monocyte HDL-C Ratio and SYNTAX Score and SYNTAX Score II in STEMI Patients Treated with

Metin Çağdaş1, Süleyman Karakoyun1, Mahmut Yesin2

  • 1Department of Cardiology, Kafkas University Medical Faculty.

Acta Cardiologica Sinica
|January 30, 2018
PubMed

Insights

The monocyte to HDL cholesterol ratio (MHR) effectively predicts coronary artery disease severity in ST-elevation myocardial infarction (STEMI) patients. Higher MHR indicates more severe coronary atherosclerosis, outperforming other inflammatory markers.

Area of Science:

  • Cardiology
  • Biomarkers
  • Interventional Cardiology

Background:

  • The monocyte to high-density-lipoprotein cholesterol ratio (MHR) reflects the balance between proatherogenic and antiatherogenic factors.
  • Elevated MHR is linked to increased coronary atherosclerosis severity and adverse cardiac events.

Purpose of the Study:

  • To investigate the association between MHR and coronary artery disease severity.
  • To evaluate MHR using SYNTAX score (SS) and SYNTAX score II (SSII) in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (pPCI).

Main Methods:

  • 264 STEMI patients treated with pPCI were analyzed.
  • Patients were stratified into low (SSII ≤ 34.2) and high (SSII > 34.2) SSII groups.
  • Correlation and multivariate analyses were performed to identify predictors of high SSII.

Main Results:

  • A significant correlation was found between MHR and SSII (r = 0.580, p < 0.001).
  • MHR was significantly higher in the high SSII group (16.1) compared to the low SSII group (10.5, p < 0.001).
  • MHR, diabetes mellitus, glomerular filtration rate, infarct-related artery (LAD), SYNTAX score, and neutrophil-to-lymphocyte ratio (NLR) were independent predictors of high SSII.

Conclusions:

  • MHR is a valuable predictor of coronary artery disease severity in STEMI patients undergoing pPCI.
  • MHR demonstrates superior predictive capability compared to NLR and C-reactive protein for assessing coronary artery disease severity in this patient cohort.
Abstract

Keywords:
Monocyte to high density cholesterol ratioST elevation myocardial infarctionSYNTAX scoreSYNTAX score II

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