Associations between Functional Connectivity Dynamics and BOLD Dynamics Are Heterogeneous Across Brain Networks
Zening Fu1,2, Yiheng Tu1,3, Xin Di4
1School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Frontiers in Human Neuroscience
|January 30, 2018
Summary
Resting-state functional brain imaging reveals that spontaneous brain activity dynamics and functional connectivity dynamics share similar spatial patterns. These dynamics are linked, with associations varying between within-network and between-network connections.
Area of Science:
- Neuroscience
- Brain Imaging
- Systems Neuroscience
Background:
- Resting-state functional brain imaging identifies two dynamic patterns: spontaneous brain activity and functional connectivity dynamics.
- These dynamics are typically studied separately, despite evidence of similar spatial patterns in functional magnetic resonance imaging (fMRI) studies.
- This suggests an underlying association between the dynamics of spontaneous brain activities and their interconnections.
Purpose of the Study:
- To characterize local blood oxygenation level dependent (BOLD) dynamics and functional connectivity dynamics (FCD) during the resting-state.
- To investigate the associations between BOLD dynamics and FCD across different brain regions.
- To explore how these associations differ for within-network versus between-network functional connectivity.
Main Methods:
- Utilized functional magnetic resonance imaging (fMRI) data acquired during the resting-state.
- Quantified BOLD dynamics by measuring the temporal variability of local BOLD signals.
- Quantified FCD by analyzing the temporal variability of time-varying functional connectivity (FC), estimated using a sliding-window correlation method.
Main Results:
- BOLD dynamics and FCD exhibited similar spatial patterns across the brain.
- Significant associations were found between BOLD dynamics and FCD across brain regions.
- These associations were heterogeneous and dependent on the type of FC: within-network FCD showed a negative correlation with BOLD dynamics, while between-network FCD showed a positive correlation.
Conclusions:
- The study demonstrates a significant, spatially heterogeneous association between spontaneous brain activity dynamics and functional connectivity dynamics.
- The opposing correlations for within-network and between-network FCD suggest distinct information processing roles.
- These findings may provide insights into the mechanisms of brain coordination and co-evolution during resting-state.
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