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Related Experiment Video

Updated: Feb 15, 2026

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Development and Functional Characterization of Murine Tolerogenic Dendritic Cells

Published on: May 18, 2018

Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity.

Matthias P Domogalla^1,2, Patricia V Rostan^1,2, Verena K Raker^1,2

¹Department of Dermatology, Division for Experimental and Translational Research, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Frontiers in Immunology

|January 30, 2018

Summary

Tolerogenic dendritic cells (DCs) hold promise for treating autoimmune diseases and transplant rejection. Research highlights methods for generating these cells and their success in clinical trials for autoimmune disorders.

Keywords:

immunotherapy nanoparticles regulatory T cells tolerance tolerogenic dendritic cells

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A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes

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Published on: April 11, 2025

Area of Science:

Immunology
Cellular Therapy

Background:

Dendritic cells (DCs) regulate immune responses, balancing tolerance and immunity.
Tolerogenic DCs are crucial for maintaining self-tolerance and preventing autoimmune diseases.
Tolerogenic DCs show potential in treating allergies, autoimmune disorders, and transplant rejection.

Purpose of the Study:

To review methods for generating human tolerogenic DCs.
To discuss mechanisms of tolerance induction by DCs, focusing on IL-10 modulation.
To examine clinical trial outcomes for tolerogenic DC therapy in autoimmune diseases.

Main Methods:

Overview of established protocols for human monocyte-derived tolerogenic DCs.
Focus on interleukin-10 (IL-10) modulated DCs.
Analysis of rodent studies demonstrating tolerogenic DC efficacy.

Main Results:

Rodent studies confirm the feasibility of tolerogenic DCs for inflammatory diseases.
Human clinical trials (Phase I) show safety and efficiency of tolerogenic DC immunotherapy.
Established protocols exist for generating human tolerogenic DCs.

Conclusions:

Tolerogenic DCs are a promising cell-based immunotherapy for autoimmune diseases and transplant rejection.
Clinical trials demonstrate the safety and efficacy of this approach.
Further research into optimal clinical-grade tolerogenic DC subsets is warranted.