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Related Concept Videos

Diffusion01:12

Diffusion

222.3K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
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Diffusion01:21

Diffusion

6.7K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
6.7K
Facilitated Diffusion01:16

Facilitated Diffusion

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The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.4K
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion03:48

Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion

31.4K
Although gaseous molecules travel at tremendous speeds (hundreds of meters per second), they collide with other gaseous molecules and travel in many different directions before reaching the desired target. At room temperature, a gaseous molecule will experience billions of collisions per second. The mean free path is the average distance a molecule travels between collisions. The mean free path increases with decreasing pressure; in general, the mean free path for a gaseous molecule will be...
31.4K
Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

5.7K
Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
5.7K
Assessment of Diffusion and Perfusion01:17

Assessment of Diffusion and Perfusion

1.7K
Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
1.7K

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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Cutaneous diffuse large B-cell lymphoma.

Filipa Duarte Ribeiro1, Henrique Coelho2, David Tente3

  • 1Internal Medicine Department Centro Hospitalar Vila Nova de Gaia/Espinho Rua Conceição Fernandes 4434-502 Vila Nova de Gaia Portugal.

Clinical Case Reports
|January 30, 2018
PubMed
Summary
This summary is machine-generated.

Cutaneous diffuse large B-cell lymphoma (cDLBCL) is a rare skin cancer with a poor prognosis. Early recognition and aggressive treatment are crucial for managing this aggressive lymphoma.

Keywords:
B cellsNon‐Hodgkin lymphomachemotherapycutaneous lesion

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Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Cutaneous diffuse large B-cell lymphoma (cDLBCL) represents approximately 6% of all primary cutaneous lymphomas.
  • cDLBCL is characterized by a generally poor prognosis.
  • Solitary lesions of cDLBCL are uncommon presentations.

Purpose of the Study:

  • To highlight the importance of recognizing rare presentations of cDLBCL.
  • To emphasize the need for prompt and effective management strategies for cDLBCL.
  • To discuss the aggressive therapeutic approach typically required for cDLBCL.

Main Methods:

  • Review of clinical presentations and treatment outcomes for cDLBCL.
  • Analysis of diagnostic criteria and prognostic factors in cDLBCL.
  • Discussion of current therapeutic guidelines for cDLBCL.

Main Results:

  • Solitary cDLBCL lesions, though rare, require careful diagnostic consideration.
  • Aggressive multi-agent chemotherapy and radiotherapy are standard treatment modalities.
  • Timely diagnosis is critical for improving patient outcomes in cDLBCL.

Conclusions:

  • Early identification of cDLBCL, including rare solitary forms, is essential.
  • An aggressive treatment strategy combining chemotherapy and radiotherapy is often necessary.
  • Prompt and appropriate management significantly impacts the prognosis of cutaneous diffuse large B-cell lymphoma.