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Fishing for cures: The alLURE of using zebrafish to develop precision oncology therapies

Matteo Astone1, Erin N Dankert1, Sk Kayum Alam1

  • 1The Hormel Institute, University of Minnesota, Austin, MN, 55912.

NPJ Precision Oncology
|January 30, 2018
PubMed

Insights

Zebrafish models offer a powerful platform for advancing cancer research and developing personalized therapies. Their genetic and biological similarities to humans enable rapid drug screening and identification of tailored cancer treatments.

Area of Science:

  • Comparative oncology
  • Zebrafish as a model organism

Background:

  • Zebrafish (Danio rerio) share genetic and histological similarities with humans (Homo sapiens).
  • They are amenable to advanced research techniques including in vivo imaging, high-throughput drug screening, mutagenesis, and transgenesis.

Purpose of the Study:

  • To highlight the emerging significance of zebrafish in precision oncology.
  • To showcase their utility in identifying cancer biomarkers, therapeutic targets, and drug discovery.
  • To explore their potential for direct clinical applications in individualized cancer treatment.

Main Methods:

  • Utilizing zebrafish for genetic cancer modeling, including advanced genome editing techniques.
  • Employing patient-derived cancer cell xenograft models in zebrafish.
  • Leveraging in vivo imaging and high-throughput screening platforms.

Main Results:

  • Zebrafish models have successfully identified tumor biomarkers and therapeutic targets.
  • Patient-derived xenografts in zebrafish serve as real-time avatars for predicting prognosis and drug response.
  • Genetic modeling facilitates the recapitulation of human oncogenesis.

Conclusions:

  • Zebrafish are a valuable tool for advancing precision oncology and developing personalized cancer therapies.
  • Their application in modeling human cancers aids in discovering novel therapeutic strategies.
  • Customizable precision therapies designed using zebrafish models promise to improve patient outcomes.
Keywords:
Danio reriobreast cancercancerdrug developmentgeneticsglioblastomaleukemialiver cancerlymphomamelanomametastasisoncogenesispancreatic cancerpatient-derived xenograftsprecision oncologyprognosissolid tumorstargeted therapytransgenic modelstumortumorigenesiszebrafish

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