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Updated: Feb 15, 2026
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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
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Insights into future therapeutics for atopic dermatitis.
Taylor Edwards1, Nupur U Patel1, Amy Blake1
1a Center for Dermatology Research, Department of Dermatology , Wake Forest School of Medicine , Winston-Salem , NC , USA.
Expert Opinion on Pharmacotherapy
|January 30, 2018
Summary
Novel targeted therapies for atopic dermatitis (AD) are advancing through clinical trials. This review examines small molecule and other agents in phase II and III, offering hope for improved AD treatment algorithms.
Area of Science:
- Dermatology
- Pharmacology
- Clinical Trials
Background:
- Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition.
- Current treatment options for AD are diverse, with ongoing research into novel therapeutic agents.
Purpose of the Study:
- To review small molecule therapies and novel agents for atopic dermatitis in clinical development.
- Focus on therapies in phase II and III clinical trials.
Main Methods:
- Literature search of PubMed and ClinicalTrials.gov.
- Compilation and assessment of clinical trial evidence for novel AD agents.
Main Results:
- Multiple novel topical and oral therapies targeting AD pathogenesis are under investigation.
- Agents include phosphodiesterase-4 inhibitors, boron molecules, Janus kinase inhibitors, and cannabinoid/kappa-opioid receptor agonists.
- Compounds with unknown mechanisms of action are also being studied.
Conclusions:
- Further clinical trials are necessary to fully understand these targeted therapies for AD.
- Successful development of targeted therapies for AD is anticipated, given their efficacy in other inflammatory diseases.
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