Related Experiment Video
Updated: Jul 29, 2026
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
The Dermatologist's Approach to Onychomycosis
Jenna N Queller1, Neal Bhatia2
1Dermatology Chief Resident at Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Jenna.Queller@gmail.com.
Journal of Fungi (Basel, Switzerland)
|January 30, 2018
Summary
New topical treatments offer effective, well-tolerated alternatives for onychomycosis (fungal nail infection). These advancements provide viable monotherapy options and support combination or maintenance therapy to reduce recurrence.
Area of Science:
- Dermatology
- Mycology
- Infectious Diseases
Background:
- Onychomycosis is a common fungal nail infection impacting nail unit components.
- It significantly affects quality of life, causing pain, disfigurement, and limitations.
- Effective management is crucial for healthcare professionals.
Purpose of the Study:
- To highlight the evolving landscape of onychomycosis treatment.
- To emphasize the growing efficacy and tolerability of topical therapies.
- To discuss the potential of new topical agents in monotherapy, combination, and maintenance strategies.
Main Methods:
- Review of recent study data on topical treatment modalities for onychomycosis.
- Analysis of treatment efficacy, tolerability, and ease of use.
- Consideration of therapeutic roles in monotherapy, combination, and post-clearance maintenance.
Main Results:
- Topical treatments for onychomycosis are demonstrating increased effectiveness compared to historical options.
- Viable, well-tolerated, and user-friendly topical monotherapy alternatives to oral treatments are emerging.
- Topical agents show promise for combination therapy and sustained treatment to prevent recurrence.
Conclusions:
- A new era of onychomycosis management is characterized by advanced topical therapies.
- Optimized use of topical agents is key for sustained clearance and reducing re-infection.
- These advancements offer improved quality of life and reduced disease burden for patients.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:30Skin Cancer
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
01:27Acne Infection
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:20Candidiasis
Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
01:15Antifungal Agents
Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...