Related Experiment Video
Updated: Feb 15, 2026

Characterizing Herbivore Resistance Mechanisms: Spittlebugs on Brachiaria spp. as an Example
Published on: June 19, 2011
Triazole Resistance in Aspergillus spp.: A Worldwide Problem?
Olga Rivero-Menendez1,2, Ana Alastruey-Izquierdo3,4, Emilia Mellado5,6
1Mycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III., Carretera de Majadahonda a Pozuelo Km. 2, Majadahonda, 28220 Madrid, Spain. orivero@isciii.es.
Azole resistance in Aspergillus fumigatus is a growing global concern. This review examines resistance mechanisms and the changing epidemiology of fungal infections, impacting clinical management.
Area of Science:
- Mycology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Azole resistance in Aspergillus fumigatus first reported in 1997 has become a worldwide issue.
- This resistance challenges the treatment of human aspergillosis.
- Emergence of azole-resistant Aspergillus species is altering disease epidemiology.
Purpose of the Study:
- To review the current status of azole resistance in Aspergillus species.
- To discuss the clinical implications of emerging azole resistance.
Main Methods:
- Literature review of studies on Aspergillus azole resistance.
- Analysis of epidemiological shifts in causative Aspergillus species.
- Review of documented resistance mechanisms.
Main Results:
- Widespread emergence of azole resistance in Aspergillus fumigatus.
- Primary resistance mechanism involves modification of the CYP51A gene encoding 14-α sterol demethylase.
- Increasing reports of other Aspergillus species causing azole-resistant infections.
Conclusions:
- Azole resistance in Aspergillus poses a significant clinical challenge.
- Understanding resistance mechanisms and epidemiological changes is crucial for effective patient management.
- Continued surveillance and research are necessary to combat rising azole resistance.
More Related Videos
08:22Author Spotlight: A New and Efficient Method for Comprehensive Metabolite Cytotoxicity Assessment of Triazole Pesticides in Plants
Published on: December 22, 2023
09:22Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Related Concept Videos
Resistivity
Resistance
Equivalent Resistance
Resistance and Conductance
Various factors impact the resistance of a conductor. Spiraling in stranded conductors increases their...
Rolling Resistance
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
Vascular Resistance
The primary determinants of vascular resistance are vessel diameter, blood viscosity, and vessel length. Among these, vessel diameter plays the most significant role due to the fourth power relationship described by...