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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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HMGB1-induced inflammatory response promotes bone healing in murine tooth extraction socket
Hiroaki Aoyagi1, Keisuke Yamashiro1, Chiaki Hirata-Yoshihara1
1Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Journal of Cellular Biochemistry
|January 30, 2018
Summary
High mobility group box 1 (HMGB1) protein promotes tooth extraction socket healing by reducing inflammation and aiding bone remodeling. Inhibiting HMGB1 with antibodies improves the healing process, offering potential therapeutic targets.
Area of Science:
- Biomedical Science
- Oral Biology
- Inflammation Research
Background:
- High mobility group box 1 (HMGB1) is an inflammatory protein.
- HMGB1's role in tooth extraction socket healing is unknown.
- Tooth extraction sockets are exposed to oral bacteria, posing healing challenges.
Purpose of the Study:
- To investigate HMGB1's role in tooth extraction socket healing.
- To assess the effect of anti-HMGB1 antibody administration on inflammation and bone healing.
- To explore HMGB1's association with angiogenesis and bone remodeling.
Main Methods:
- Murine tooth extraction model with anti-HMGB1 antibody administration.
- Molecular imaging of myeloperoxidase (MPO) activity.
- Histological analysis and quantitative RT-PCR.
Main Results:
- Anti-HMGB1 antibody inhibited HMGB1 translocation and reduced MPO activity.
- Decreased CD31+, CD68+, TRAP+, and osteocalcin+ cells observed.
- Reduced neoplastic bone area and suppressed IL-1β and VEGF-A expression.
Conclusions:
- Secreted HMGB1 drives acute inflammation and inflammatory cell recruitment post-extraction.
- HMGB1 promotes angiogenesis and bone remodeling via osteoclast/osteoblast activation.
- HMGB1 is crucial for promoting bone healing in tooth extraction sockets.
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