Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

335
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
335
Theory of Romantic Attachment in Adulthood03:34

Theory of Romantic Attachment in Adulthood

50.0K
Attachment is a long-standing connection or bond with others. While Attachment Theory was conceived in developmental psychology to describe infant-caregiver bonding, it's been extended into adulthood to include romantic relationships. 
50.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Placental pathology and weight following Intrauterine Insemination (IUI) with or without ovarian stimulation (OS).

Placenta·2026
Same author

Standardized Placental Pathology Reporting: Improving Quality and Clinical Utility Recommendations From the Society for Pediatric Pathology Placental Pathology Reporting Task Force.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·2026
Same author

Pulmonary valve cusp autotransplantation for complex aortic valve reconstruction in biventricular conversion.

JTCVS techniques·2026
Same author

Biventricular Pressure-Volume Area Ratio for the Assessment of Left Ventricular Preparedness for Double Switch Operation.

JACC. Advances·2026
Same author

Surgical Management and Long-Term Outcomes of Patients With Superior-Inferior Ventricles.

JACC. Advances·2025
Same author

Serotonergic receptor binding in the brainstem in the Sudden Infant Death Syndrome in a high-risk population.

PloS one·2025

Related Experiment Video

Updated: Feb 15, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K

Stillborn Infants: Associated Malformations.

Lewis B Holmes1,2,3, Hanah Nasri1,2, Rebecca Beroukhim4

  • 1Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, Massachusetts.

Birth Defects Research
|January 30, 2018
PubMed
Summary

Stillbirths with malformations are more severe than in live births. Autopsies, including genetic testing, help identify causes and improve future pregnancy counseling.

Keywords:
45,Xheart defectslethalsevere-handicapping malformationsstillbirthtrisomies

More Related Videos

Author Spotlight: Marmoset Research - Scope and Challenges
04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.7K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.8K

Related Experiment Videos

Last Updated: Feb 15, 2026

P50 Sensory Gating in Infants
12:55

P50 Sensory Gating in Infants

Published on: December 26, 2013

9.6K
Author Spotlight: Marmoset Research - Scope and Challenges
04:52

Author Spotlight: Marmoset Research - Scope and Challenges

Published on: June 9, 2023

2.7K
A Patient-Derived Xenograft Model for Venous Malformation
06:51

A Patient-Derived Xenograft Model for Venous Malformation

Published on: June 15, 2020

5.8K

Area of Science:

  • Perinatal pathology
  • Medical genetics
  • Congenital malformations

Background:

  • Stillbirth, defined as fetal death after 20 weeks gestation, affects 1-2% of US pregnancies.
  • Associated factors include fetal malformations (chromosomal, neural tube, syndromes), placental abnormalities, and maternal conditions (pre-eclampsia, obesity).
  • Studying malformed stillborn infants reveals the frequency and severity of associated anomalies.

Purpose of the Study:

  • To analyze the frequency and severity of malformations in stillborn infants.
  • To identify common lethal malformations and heart defects in stillbirths.
  • To assess the utility of postmortem examinations for parental counseling.

Main Methods:

  • Utilized data from the Active Malformations Surveillance Program (1972-2012).
  • Compiled autopsy findings, placental examinations, and diagnostic study results for stillborn infants.
  • Focused on a consecutive sample of malformed stillborn infants.

Main Results:

  • Identified 127 stillborn infants with malformations among 289,365 pregnancies.
  • Common findings included trisomies (21, 18, 13), 45,X, triploidy, anencephaly, urinary tract obstruction, holoprosencephaly, and severe heart defects.
  • Malformations in stillborn infants were more severe than those observed in live-born infants.

Conclusions:

  • Postmortem examination, including chromosome microarray and placental analysis, identifies stillbirth causes.
  • Lethal malformations and heart defects are more prevalent in stillborn fetuses compared to live births.
  • Postmortem examinations enhance parental counseling regarding future pregnancy risks.