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Updated: Feb 15, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
Published on: October 31, 2016
Controlled Formation and Binding Selectivity of Discrete Oligo(methyl methacrylate) Stereocomplexes
Jing M Ren1, Jimmy Lawrence, Abigail S Knight
1Department of Chemical Engineering, The University of Melbourne , Parkville, Victoria 3010, Australia.
Abstract:
The triple-helix stereocomplex of poly(methyl methacrylate) (PMMA) is a unique example of a multistranded synthetic helix that has significant utility and promise in materials science and nanotechnology. To gain a fundamental understanding of the underlying assembly process, discrete stereoregular oligomer libraries were prepared by combining stereospecific polymerization techniques with automated flash chromatography purification. Stereocomplex assembly of these discrete building blocks enabled the identification of (1) the minimum degree of polymerization required for the stereocomplex formation and (2) the dependence of the helix crystallization mode on the length of assembling precursors. More significantly, our experiments resolved binding selectivity between helical strands with similar molecular weights. This presents new opportunities for the development of next-generation polymeric materials based on a triple-helix motif.
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