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Updated: Feb 15, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

Published on: September 19, 2017

Single-molecule manipulation and detection.

Deyu Zhao¹, Siyun Liu¹, Ying Gao^1,2

¹State Key Laboratory of Molecular Biology, National Center for Protein Science Shanghai, Shanghai Science Research Center, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 201210, China.

Acta Biochimica Et Biophysica Sinica

|January 30, 2018

Summary

This summary is machine-generated.

Single-molecule techniques offer unprecedented insights into biological reactions, surpassing traditional methods. This review surveys advanced tools like optical tweezers and atomic force microscopy (AFM) for manipulating and detecting single molecules.

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Last Updated: Feb 15, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers

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Published on: September 19, 2017

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Area of Science:

Biophysics
Biochemistry
Molecular Biology

Background:

Conventional ensemble methods obscure individual molecular behaviors.
Single-molecule studies provide high-resolution views of biological processes.
Recent advancements have revolutionized molecular manipulation and detection.

Purpose of the Study:

To review cutting-edge single-molecule techniques.
To describe the principles and applications of these methods.
To provide an introductory survey for researchers.

Main Methods:

Optical tweezers
Magnetic tweezers
Atomic force microscopy (AFM)
Hydrodynamic flow-stretching assay
Single-molecule fluorescence resonance energy transfer (smFRET)

Main Results:

These techniques enable precise manipulation and detection of single molecules.
Each method offers unique advantages for studying molecular mechanisms.
Applications span various areas of biological research.

Conclusions:

Single-molecule techniques are essential for understanding complex biological reactions.
These advanced methods offer clearer and sometimes surprising biological insights.
The review serves as a foundational guide to these powerful tools.