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Updated: Feb 15, 2026

ATAC-Seq Optimization for Cancer Epigenetics Research
Published on: June 30, 2022
Cervical Cancer Markers: Epigenetics and microRNAs
Vishuda Laengsri1,2, Usanee Kerdpin3, Chotiros Plabplueng1,2
1Center for Research & Innovation, Mahidol University, Bangkok, Thailand.
Abstract:
Gynecologic malignant neoplasms are a severe health problem among female patients, of which cervical cancer (CC), in particular, is a common disease leading to high mortality rates. Despite extensive attempts by researchers to solve the molecular mystery of CC, the mechanisms of its pathogenesis remain unclear. Tumor markers used in the clinical laboratory, such as squamous cell carcinoma (SCC), cancer antigen (CA)-125, and CA19-9, provide some help in diagnosing patients with CC. However, finding new molecular markers with high sensitivity and specificity is necessary. This review focuses on the role of epigenetic changes, particularly microRNAs (miRNAs), to CC. Several miRNAs that associated with CC potentially have the advantage of being early biomarkers. Moreover, altered serum miRNAs or single nucleotide polymorphisms in miRNA patterns may predict disease progression.
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