Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Gene Expression?01:42

What is Gene Expression?

197.2K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.2K
What is Gene Expression?01:36

What is Gene Expression?

11.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.6K
5.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

25.0K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
25.0K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frontoparietal control-default mode connectivity predicts TMS effects on cognitive control.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Patterns of Muscle Health in Single- and Multi-Site Chronic Pain: A UK Biobank Normative Modeling Study.

medRxiv : the preprint server for health sciences·2026
Same author

Shared neural geometries for bilingual semantic representations in human hippocampal neurons.

Cell·2026
Same author

Immune Aging is an Independent Risk Factor for Cardiovascular Disease.

bioRxiv : the preprint server for biology·2026
Same author

Detecting Features of Interpersonal Difficulties in First-Person Accounts of Schizophrenia; Automated Linguistic and Network Analyses.

Schizophrenia bulletin open·2026
Same author

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity.

The Journal of experimental medicine·2026

Related Experiment Video

Updated: Feb 15, 2026

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
10:34

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

Published on: April 14, 2010

16.0K

Commensal microbiota modulate gene expression in the skin.

Jacquelyn S Meisel1, Georgia Sfyroera1, Casey Bartow-McKenney1

  • 1Department of Dermatology, University of Pennsylvania Perelman School of Medicine, 421 Curie Blvd, 1015 BRB II/III, Philadelphia, PA, 19104, USA.

Microbiome
|January 31, 2018
PubMed
Summary

The skin microbiome significantly influences gene expression, modulating immune responses and epidermal development. This study reveals key molecular pathways connecting microbes to skin health and disease.

Keywords:
Cutaneous transcriptomeGerm-free miceHost-microbe interactionsRNA sequencingSkin microbiome

More Related Videos

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

8.6K
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.7K

Related Experiment Videos

Last Updated: Feb 15, 2026

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
10:34

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

Published on: April 14, 2010

16.0K
Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
09:23

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans

Published on: August 16, 2017

8.6K
Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.7K

Area of Science:

  • Microbiology
  • Genomics
  • Dermatology

Background:

  • The skin hosts diverse microbial communities with largely unknown functions.
  • Understanding cutaneous host-microbe interactions and molecular mechanisms is crucial.

Purpose of the Study:

  • To investigate the impact of the skin microbiota on host gene expression.
  • To elucidate pathways and functions modulated by microbes in the skin.

Main Methods:

  • Profiled skin transcriptomes of mice with and without microbiota.
  • Analyzed differentially regulated genes and enriched gene ontology (GO) terms.

Main Results:

  • 2820 genes were differentially regulated by microbial colonization.
  • Microbiota influenced immune response (e.g., toll-like receptors, cytokines) and epidermal differentiation (EDC genes).
  • Identified shared transcriptional signatures between skin and gut microbiota regulation.

Conclusions:

  • Established a foundational resource for understanding microbially mediated gene expression in skin.
  • Highlighted the microbiome's role in skin health and disease through genome-wide implications.