Related Experiment Video
Updated: Feb 15, 2026
17:59
Derivation of Thymic Lymphoma T-cell Lines from Atm-/- and p53-/- Mice
Published on: April 3, 2011
12.7K
Intravascular lymphoma presenting with postural hypotension
Catharine Pearce1, Suzy Hope1,2, Joseph Butchart1
1Healthcare for Older People Department, Royal Devon and Exeter NHS Foundation Trust, Exeter, UK.
BMJ Case Reports
|January 31, 2018
Summary
Intravascular lymphoma can cause severe postural hypotension due to autonomic neuropathy. Successful chemotherapy treatment resolved the hypotension, though some instability remains.
Area of Science:
- Oncology
- Neurology
- Dermatology
Background:
- Intravascular lymphoma is a rare B-cell neoplasm characterized by malignant lymphocytes confined to blood vessels.
- Autonomic neuropathy can manifest as postural hypotension, impacting cardiovascular regulation.
Observation:
- An 84-year-old woman presented with severe postural hypotension, weight loss, fatigue, and night sweats.
- Physical examination revealed bilateral inner thigh skin lesions; biopsy confirmed intravascular high-grade B-cell lymphoma.
Findings:
- The patient's intravascular lymphoma was treated with curative chemotherapy.
- Postural hypotension was attributed to neurovascular infiltration by the lymphoma, causing autonomic neuropathy.
Implications:
- This case highlights a rare presentation of intravascular lymphoma.
- Successful lymphoma treatment can reverse chemotherapy-induced autonomic neuropathy and resolve postural hypotension.
- Persistent postural instability suggests potential long-term neurological sequelae.
