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Related Concept Videos

Pulse Oximetry01:24

Pulse Oximetry

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Pulse oximetry, or SpO2, is a non-invasive method for continuously monitoring arterial oxygen saturation (SaO2). This procedure involves attaching a probe or sensor to the patient's fingertip, forehead, earlobe, or nose bridge. The sensor works by detecting changes in oxygen saturation levels through light signals generated by the oximeter and reflected by the pulsing blood under the probe.
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
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Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.3K
Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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Health Information Technology and Healthcare Information System01:30

Health Information Technology and Healthcare Information System

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Health Information Technology (HIT)
Health Information Technology, commonly called HIT, integrates advanced information systems and technology in healthcare settings. Its primary functions include:
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Related Experiment Video

Updated: Feb 15, 2026

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
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In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma

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Glaucoma related retinal oximetry: a technology update.

Zhu Li Yap1,2, Sushma Verma2, Yi Fang Lee1,2

  • 1Singapore National Eye Center.

Clinical Ophthalmology (Auckland, N.Z.)
|January 31, 2018
PubMed
Summary

Glaucoma pathogenesis theories include barotrauma and vascular hypoxia. Retinal oximetry, a novel technique, measures oxygen saturation in retinal vessels, offering insights into the vascular theory of glaucoma.

Keywords:
Oxymapglaucomaglaucoma imagingretinal oximetryretinal vasculature

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Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
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Related Experiment Videos

Last Updated: Feb 15, 2026

In Vivo Dynamics of Retinal Microglial Activation During Neurodegeneration: Confocal Ophthalmoscopic Imaging and Cell Morphometry in Mouse Glaucoma
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Area of Science:

  • Ophthalmology
  • Vascular Biology
  • Medical Imaging

Background:

  • Glaucoma pathogenesis is debated, with theories including barotrauma and vascular hypoxia.
  • The relationship between diminished blood flow and glaucomatous optic nerve atrophy remains unclear.
  • Existing ocular blood flow imaging lacks direct metabolic assessment or oxygen carrying capacity measurement.

Purpose of the Study:

  • To review ocular imaging techniques and current retinal oximetry methods.
  • To contextualize studies investigating the vascular theory of glaucoma using oximetry.
  • To highlight the clinical significance of retinal oximetry in glaucoma research.

Main Methods:

  • Overview of established ocular imaging modalities.
  • Description of novel, noninvasive retinal oximetry techniques.
  • Synthesis of findings from key oximetry studies in glaucoma.

Main Results:

  • Retinal oximetry reliably measures oxygen saturation in retinal vessels.
  • Oximetry provides surrogate markers for ocular metabolic demands.
  • Clinical significance of oximetry measurements in glaucoma is under investigation.

Conclusions:

  • Retinal oximetry is a promising tool for studying glaucoma's vascular aspects.
  • Further research is needed to establish the full clinical significance of oximetry in glaucoma.
  • Oximetry aids in understanding the role of vascular hypoxia in glaucoma pathogenesis.