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Effect of sevoflurane and halothane anesthesia on cognitive function and immune function in young rats
Jian-Hua Qin1, Xue-Rong Zhang1, Liang He1
1Department of Aneshesiology, People's of Hospital of Xinjiang Uygur Autonomous Region, Urumchi 830001, China.
Saudi Journal of Biological Sciences
|January 31, 2018
Summary
Sevoflurane and halothane anesthesia impact young rats' cognitive and immune functions. Sevoflurane may mitigate halothane's negative effects on rat brain and behavior.
Area of Science:
- Neuroscience
- Immunology
- Anesthesiology
Background:
- Anesthetic agents like sevoflurane and halothane are widely used.
- Their effects on cognitive and immune functions, especially in young subjects, require further investigation.
Purpose of the Study:
- To investigate the impact of sevoflurane and halothane on cognitive and immune functions in young rats.
- To determine if sevoflurane can modulate the effects of halothane.
Main Methods:
- Young rats were divided into sevoflurane, halothane, and combined sevoflurane + halothane groups.
- Cognitive function was assessed using the water maze test.
- Serum proinflammatory cytokines (IL-10, IL-4, IL-2), brain IL-1β levels, and hippocampal neuronal apoptosis were measured.
Main Results:
- Both sevoflurane and halothane groups showed altered latency in the water maze test.
- Hippocampal neuronal apoptosis increased in halothane and combined groups.
- Proinflammatory cytokines IL-10 and IL-4 increased, while brain IL-1β decreased in anesthetic groups compared to controls.
Conclusions:
- Sevoflurane and halothane anesthesia affect cognitive and immune functions in young rats.
- Sevoflurane appears to inhibit the adverse anesthetic effects of halothane on immune and cognitive parameters.
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