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Enteric parasites can disturb leptin and adiponectin levels in children

Raida S Yahya1, Soha I Awad2,3, Nadeem Kizilbash4

  • 1Department of Laboratory Medicine, Children's' Hospital, Faculty of Medicine, Mansoura University, Egypt.

Archives of Medical Science : AMS
|January 31, 2018
PubMed

Insights

Childhood intestinal parasite infections can disrupt white adipose tissue hormones like leptin and adiponectin. This study found specific parasite infections altered these hormone levels, impacting child health.

Area of Science:

  • Pediatric Endocrinology
  • Parasitology
  • Nutritional Science

Background:

  • Childhood intestinal parasite infections are linked to health issues like anemia and anorexia.
  • These infections may affect nutritional status and overall development.
  • White adipose tissue hormones play a crucial role in metabolic regulation.

Purpose of the Study:

  • To investigate the impact of various intestinal parasite infections on serum leptin and adiponectin levels in children.
  • To assess the relationship between parasitic infections, body mass index (BMI), and hormonal changes.

Main Methods:

  • A study involving 81 children with parasitic infections and 35 healthy controls.
  • Clinical examinations, BMI measurements, and laboratory analyses were performed.
  • Serum levels of leptin and adiponectin were measured.

Main Results:

  • Uninfected children showed increased leptin and decreased adiponectin with BMI percentile changes.
  • Children infected with *E. histolytica*, *Strongyloides*, or *E. histolytica* and *Giardia* exhibited significant alterations in leptin and adiponectin levels compared to controls.
  • No significant hormonal changes were observed in the overall infected group compared to controls initially.

Conclusions:

  • Certain intestinal parasite infections can deregulate leptin and adiponectin secretion in children.
  • These hormonal disturbances may contribute to altered BMI and anorexia.
  • Understanding these effects is vital for managing childhood health complications associated with parasitic infections.
Abstract

Keywords:
Entamoeba histolyticaStrongyloides stercoralisadiponectinanorexiabody mass indexleptin

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