Impaired Oxidative Status Is Strongly Associated with Cardiovascular Risk Factors

Area of Science:

• Cardiovascular disease research
• Oxidative stress and disease
• Preventive cardiology

Background:

• Cardiovascular risk factors are key targets for primary prevention.
• Altered oxidative status is linked to various pathologies, including cardiovascular diseases.
• The prognostic value of oxidative stress biomarkers is not fully understood.

Purpose of the Study:

• To investigate the association between oxidative status and cardiovascular risk factors in a healthy population.
• To identify specific risk factors that impact oxidative status and the antioxidant barrier.

Main Methods:

• Analysis of oxidative status in plasma samples from a healthy cohort (n=322).
• Correlation of oxidative status markers with traditional cardiovascular risk factors.
• Assessment of age-related and metabolic disorder-related alterations in oxidative status.

Main Results:

• Plasmatic oxidative status is significantly associated with traditional cardiovascular risk factors.
• A notable depletion of the total plasma antioxidant barrier was observed in high cardiovascular risk categories.
• Cholesterol imbalance emerged as the primary factor diminishing antioxidant barrier efficacy.
• Hypertension, particularly increased systolic blood pressure, significantly impacts oxidative status.
• Age and metabolic disorders also showed significant correlations with altered oxidative status.

Conclusions:

• Circulating oxidative status is closely linked to cardiovascular risk factors in healthy individuals.
• The plasma antioxidant barrier's efficacy is compromised by high cardiovascular risk, metabolic disorders, and cholesterol imbalance.
• Early signs of redox disturbance manifest as overutilization and depletion of the antioxidant barrier.