Related Experiment Video

Updated: Feb 15, 2026

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

14.3K

Cryptosporidium species subtypes and associated clinical manifestations in Indian patients

Shehla Khalil1, Bijay Ranjan Mirdha1, Ashutosh Panda1

  • 1Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

Gastroenterology and Hepatology From Bed to Bench
|January 31, 2018
PubMed
Abstract

Insights

This study identified Cryptosporidium species in diarrheic patients, finding Cryptosporidium hominis and Cryptosporidium parvum as dominant species. Molecular subtyping revealed significant diversity, highlighting the anthroponotic nature of human cryptosporidiosis.

Area of Science:

  • Medical Parasitology
  • Molecular Epidemiology
  • Infectious Diseases

Background:

  • Cryptosporidium species are significant causes of parasitic diarrhea.
  • Cryptosporidium hominis and Cryptosporidium parvum are the primary species responsible for human cryptosporidiosis.

Purpose of the Study:

  • To investigate the distribution of Cryptosporidium species and subtypes in patients presenting with diarrhea at a tertiary care center.
  • To contribute molecular epidemiological data to understand human cryptosporidiosis.

Main Methods:

  • Enrolled 450 patients with diarrhea.
  • Employed both microscopic and molecular diagnostic methods (Polymerase Chain Reaction - PCR) for detection, speciation, and subtyping of Cryptosporidium.

Main Results:

  • 43 out of 450 patients tested positive for Cryptosporidium via PCR.
  • Cryptosporidium hominis (70%) and Cryptosporidium parvum (21%) were the most prevalent species.
  • Subtyping identified 16 subtypes within 8 different subtype families for C. hominis and C. parvum.

Conclusions:

  • The findings support the anthroponotic origin of most human cryptosporidiosis cases.
  • The molecular epidemiological data provides insights into the evolving clinical landscape of human cryptosporidiosis.
Keywords:
CryptosporidiumGenetic variationsGlycoprotein gp60phylogeny

More Related Videos

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection05:31

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Published on: September 14, 2019

10.2K
Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides05:16

Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides

Published on: May 7, 2020

7.3K

Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
898
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
272
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
579
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
386
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
700
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
642