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Updated: Feb 15, 2026

A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
George Fotakopoulos1,1, Kostas Fountas1,1, Eleni Tsianaka1,1
1Department of Neurosurgery, University Hospital of Thessaly, University Hospital of Larissa, Biopolis, 41110 Larissa, Thessaly, Greece.
Aim:
To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection.
Patients & Methods:
This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient.
Results:
Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001).
Conclusion:
Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS.
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