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Updated: Feb 15, 2026

Modeling Persistent Pseudomonas aeruginosa Infection in Wounded Zebrafish Larvae
Published on: June 13, 2025
Pseudomonas aeruginosa Takes a Multi-Target Approach to Achieve Junction Breach
Guillaume Golovkine1, Emeline Reboud1, Philippe Huber1
1Centre National de la Recherche Scientifique ERL5261, CEA BIG-BCI, Institut National de la Santé et de la Recherche Médicale UMR1036, Université Grenoble Alpes, Grenoble, France.
Abstract:
Pseudomonas aeruginosa is an opportunistic pathogen which uses a number of strategies to cross epithelial and endothelial barriers at cell-cell junctions. In this review, we describe how the coordinated actions of P. aeruginosa's virulence factors trigger various molecular mechanisms to disarm the junctional gate responsible for tissue integrity.
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