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Related Experiment Video

Updated: Feb 15, 2026

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

Published on: September 11, 2017

Layer-specific Developmental Changes in Excitation and Inhibition in Rat Primary Visual Cortex.

Roberta Tatti¹, Olivia K Swanson^1,2, Melinda S E Lee¹

¹Department of Neurobiology and Behavior, SUNY - Stony Brook, Stony Brook, NY.

|January 31, 2018

Summary

Delayed eye opening in rats impacts visual cortex development. Unilateral delays cause long-lasting, layer-specific changes in synaptic transmission, highlighting experience

Keywords:

Development excitation experience inhibition visual cortex

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Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex

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Published on: February 8, 2020

Area of Science:

Neuroscience
Developmental Neuroscience
Visual System Development

Background:

Postnatal development profoundly shapes cortical circuits through experience.
Ocular dominance plasticity in the primary visual cortex (V1) is well-studied, but the impact of natural events like eye opening on microcircuit maturation is less understood.

Purpose of the Study:

To investigate how manipulating the timing of eye opening affects synaptic transmission in rat V1.
To determine if these effects are uniform across cortical layers or laminar-specific.

Main Methods:

Slice electrophysiology and immunohistochemistry in rat V1.
Manipulation of eye opening timing (delayed binocular or unilateral).
Assessment of excitatory and inhibitory synaptic transmission onto excitatory neurons across cortical layers.

Main Results:

A 3-day delay in binocular eye opening reduced excitatory and inhibitory synaptic transmission uniformly across layers 2/3, 4, and 5.
Synaptic transmission recovered with a 7-day binocular delay, indicating duration-dependence.
Unilateral eye opening delays induced laminar-specific and long-lasting effects.

Conclusions:

Pyramidal neurons in different cortical laminae exhibit distinct sensitivities to altered sensory input.
Experience is crucial for both the maturation of synaptic transmission and its coordinated regulation across cortical layers.