Towards multi-phase postmortem CT angiography in children: a study on a porcine model

Area of Science:

• Forensic radiology
• Pediatric imaging techniques
• Vascular imaging

Background:

• Multi-phase postmortem computed tomography angiography (MPMCTA) is a standardized adult imaging technique.
• Its application in pediatric populations requires adaptation and validation.
• Porcine models offer a viable alternative for studying pediatric imaging protocols.

Purpose of the Study:

• To adapt the adult MPMCTA protocol for pediatric use.
• To evaluate the efficacy of MPMCTA in a porcine model across various weights.
• To identify optimal parameters for pediatric vascular imaging.

Main Methods:

• Three groups of pigs (n=18 each) weighing 4-48 kg were studied.
• Different pump devices (Virtangio®, Medrad®) were utilized.
• Vascular opacification was semi-quantitatively assessed in 52 arterial and venous segments.

Main Results:

• Complete opacification was achieved in thoracic, abdominal, and pelvic regions.
• The Medrad® machine demonstrated superior opacification in extremities for smaller pigs.
• Lower pig weights correlated with higher opacification percentages and lower contrast volumes.

Conclusions:

• Postmortem computed tomography angiography (PMCTA) is feasible in pediatric subjects, especially those weighing as little as 4 kg, using the Medrad® machine.
• The adapted protocol shows promise for pediatric applications.
• Further research is necessary to refine the procedure for optimal pediatric imaging.