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Updated: Feb 15, 2026

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

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Prostate cancer detection in patients with prior negative biopsy undergoing cognitive-, robotic- or in-bore MRI

Sascha Kaufmann1,2, Giorgio I Russo3,4, Fabian Bamberg1

  • 1Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str.3, 72076, Tübingen, Germany.

World Journal of Urology
|January 31, 2018
PubMed
Abstract

Insights

Robot-assisted MRI/TRUS fusion (RA-TB) and in-bore MRI guided biopsy (MRGB) show higher prostate cancer (PC) detection rates than cognitive fusion biopsy (COG-TB). These targeted biopsy methods improve accuracy for detecting both PC and clinically significant PC (csPC).

Area of Science:

  • Urology
  • Oncology
  • Medical Imaging

Background:

  • Prostate cancer (PC) diagnosis relies on accurate detection of tumors.
  • Targeted biopsy (TB) techniques aim to improve diagnostic accuracy over traditional methods.
  • Comparing different TB approaches is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To compare the detection rates of prostate cancer (PC) and clinically significant PC (csPC) using three targeted biopsy (TB) methods.
  • Evaluate robot-assisted MRI/TRUS fusion (RA-TB), in-bore MRI guided biopsy (MRGB), and cognitive fusion biopsy (COG-TB).

Main Methods:

  • A cohort of 156 patients with suspicious MRI lesions underwent one of three TB techniques: RA-TB, MRGB, or COG-TB.
  • Lesions were assessed using PI-RADS v2 criteria.
  • Detection rates for PC and csPC were compared, and predictive models were developed.

Main Results:

  • Overall PC detection rates were 52.42% for RA-TB, 51.11% for MRGB, and 28.95% for COG-TB (p=0.04).
  • Clinically significant PC (csPC) detection rates were 35.62% for RA-TB, 40.0% for MRGB, and 23.68% for COG-TB (p=0.27).
  • RA-TB and MRGB were significantly associated with overall PC detection, while MRGB was associated with csPC detection.

Conclusions:

  • In-bore MRI guided biopsy (MRGB) and MRI/TRUS fusion-guided biopsy (RA-TB) demonstrate superior accuracy in detecting prostate cancer compared to cognitive fusion biopsy (COG-TB).
  • These findings support the use of advanced fusion techniques for more precise PC diagnosis.
Keywords:
Cognitive prostate biopsyIn-bore prostate biopsyNomogramProstate cancerRobot-assisted fusion biopsy

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