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Updated: Feb 15, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
Published on: May 18, 2020
Developmental Origins of Breast Cancer: A Paternal Perspective
Camile Castilho Fontelles1,2, Raquel Santana da Cruz2, Leena Hilakivi-Clarke2
1Department of Food and Experimental Nutrition, Food Research Center (FoRC), Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
Abstract:
The developmental origins of breast cancer have been considered predominantly from a maternal perspective. Although accumulating evidence suggests a paternal programming effect on metabolic diseases, the potential impact of fathers' experiences on their daughters' breast cancer risk has received less attention. In this chapter, we focus on the developmental origins of breast cancer and examine the emerging evidence for a role of fathers' experiences.
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