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N-terminal pro-B-type natriuretic peptide and prognosis in Caucasian vs. Asian patients with heart failure

Jasper Tromp1,2, Arthur Mark Richards3,4, Wan Ting Tay2

  • 1Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

ESC Heart Failure
|January 31, 2018
PubMed

Insights

N-terminal pro-B-type natriuretic peptide (NT-proBNP) effectively predicts heart failure outcomes in both Asian and Caucasian populations. This heart failure biomarker shows consistent prognostic utility across diverse ethnicities, confirming its value in clinical practice.

Area of Science:

  • Cardiology
  • Biomarkers
  • Ethnic Health Disparities

Background:

  • N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a key biomarker for diagnosing and managing heart failure (HF).
  • The prognostic significance of NT-proBNP across different ethnic groups, particularly Caucasians and Asians, requires further investigation due to potential variations in clinical determinants.

Purpose of the Study:

  • To evaluate and compare the prognostic utility of NT-proBNP in Caucasian and Asian patients hospitalized for heart failure.
  • To determine if ethnic differences in clinical characteristics influence the predictive performance of NT-proBNP for adverse outcomes.

Main Methods:

  • A comparative study involving 546 Caucasian HF patients and 578 Asian HF patients.
  • NT-proBNP levels were measured at discharge; the primary outcome was a composite of all-cause mortality and HF hospitalization at 18 months.
  • Statistical analyses were performed to assess the association of NT-proBNP with outcomes, accounting for ethnicity and clinical covariates.

Main Results:

  • Despite significant differences in age, sex, body mass index, renal function, and comorbidities like diabetes and hypertension, mean NT-proBNP levels were similar between Asian and Caucasian patients.
  • NT-proBNP demonstrated a strong association with the composite outcome (all-cause mortality and HF hospitalization) with a hazard ratio of 1.28 per doubling.
  • This prognostic association of NT-proBNP was consistent across both ethnic groups (Pinteraction = 0.719) and in patients with HF with reduced or preserved ejection fraction.

Conclusions:

  • NT-proBNP serves as a reliable prognostic biomarker for heart failure patients, irrespective of their ethnicity.
  • The study confirms the comparable prognostic performance of NT-proBNP in Asian and Caucasian populations, underscoring its universal applicability in heart failure management.
Abstract

Keywords:
EthnicityHFpEFHeart failureNT-proBNPPrognosis

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