Mesh Nanoelectronics: Seamless Integration of Electronics with Tissues

Area of Science:

• Nanobioelectronics
• Biotechnology
• Medical Devices

Background:

• Integrating electronics with biological systems faces challenges due to size and mechanical property mismatches.
• Mesh nanoelectronics offer a novel solution for seamless integration with synthetic tissues and live animals.

Purpose of the Study:

• To discuss the concept, development, and applications of mesh nanoelectronics.
• To highlight mesh nanoelectronics as a paradigm for integrating electronics within tissues and animals.
• To explore future opportunities in nanobioelectronics.

Main Methods:

• Design and realization of 3D hybrid synthetic tissues with mesh nanoelectronics.
• Development of ultraflexible mesh nanoelectronics for minimally invasive implantation into rodent brains.
• Utilizing syringe-injection methodology for precise delivery of nanoelectronics.

Main Results:

• Demonstrated real-time 3D recording of electrophysiological and chemical signals in neural tissue, cardiac patches, and vascular constructs.
• Showcased stable integration of mesh nanoelectronics in rodent brains for over a year without adverse tissue response.
• Achieved stable, long-term multiplexed neural recordings and stimulation for up to 8 months.

Conclusions:

• Mesh nanoelectronics provide a versatile platform for bidirectional interfaces with biological tissues.
• This technology facilitates long-term monitoring and modulation of tissue and neural activity.
• Mesh nanoelectronics hold significant potential for regenerative medicine, neuroprosthetics, and understanding aging-related neurological changes.