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Updated: Feb 15, 2026

A Novel Technique for Raman Analysis of Highly Radioactive Samples Using Any Standard Micro-Raman Spectrometer
Published on: April 12, 2017
Multivariate Analysis To Quantify Species in the Presence of Direct Interferents: Micro-Raman Analysis of HNO3 in
Amanda M Lines1, Gilbert L Nelson2, Amanda J Casella1
1Energy and Environment Directorate, Pacific Northwest National Laboratory , Richland, Washington 99352, United States.
Abstract:
Microfluidic devices are a growing field with significant potential for applications to small scale processing of solutions. Much like large scale processing, fast, reliable, and cost-effective means of monitoring streams during processing are needed. Here we apply a novel micro-Raman probe to the online monitoring of streams within a microfluidic device. For either macro- or microscale process monitoring via spectroscopic response, interfering or confounded bands can obfuscate results. By utilizing chemometric analysis, a form of multivariate analysis, species can be accurately quantified in solution despite the presence of overlapping or confounding spectroscopic bands. This is demonstrated on solutions of HNO3 and NaNO3 within microflow and microfluidic devices.
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