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Updated: Feb 15, 2026
05:19
A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
883
Next-generation prostate cancer risk calculator for primary care physicians
Robert K Nam1, Raj Satkunavisam1, Joseph L Chin2
1Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
Summary
A new prostate cancer risk calculator integrates life expectancy, improving risk assessment for patients. This tool aids in evaluating prostate cancer risk considering age and comorbidities for better clinical decisions.
Area of Science:
- Urology
- Oncology
- Biostatistics
Background:
- Current prostate cancer risk calculators offer limited clinical utility by providing only a probability of disease.
- Existing tools do not adequately contextualize risk relative to a patient's life expectancy, age, or comorbidities.
Purpose of the Study:
- To develop a next-generation prostate cancer risk calculator incorporating life expectancy.
- To enhance the evaluation of prostate cancer risk by considering patient-specific factors.
Main Methods:
- Combined two cohorts: 5,638 men undergoing prostate biopsy and 979 men with prostate cancer and survival data.
- Developed two multivariable regression models to create nomograms for cancer risk and survival prediction.
- Created an online, next-generation prostate cancer risk calculator.
Main Results:
- The risk calculator achieved a concordance index of 0.74 for cancer risk and 0.71 for survival prediction.
- Identified aggressive prostate cancer in 11% of biopsy patients.
- The 10-year overall survival for treated prostate cancer patients was 49.6%.
Conclusions:
- A novel prostate cancer risk calculator integrating life expectancy, age, and comorbidity has been developed.
- This enhanced tool provides a more comprehensive evaluation of prostate cancer risk.
- Further validation in diverse populations is recommended.
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