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Fabrication of Decellularized Cartilage-derived Matrix Scaffolds
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Novel Topologically Complex Scaffold Derived from Alkaloid Haemanthamine.
Karthik Govindaraju1, Marco Masi2, Margaux Colin3
1Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX 78666, USA. gkiict@gmail.com.
Molecules (Basel, Switzerland)
|February 1, 2018
Summary
Researchers transformed the alkaloid haemanthamine into a novel complex structure using a ring-closing iodoalkoxylation reaction. This work demonstrates a new pathway for generating diverse natural product-like compounds for drug discovery.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Natural Products Chemistry
Background:
- Low hit rates in synthetic libraries necessitate new methods for compound generation.
- Natural products offer unique chemical scaffolds not easily accessible synthetically.
- Exploring novel chemical space is crucial for drug discovery.
Purpose of the Study:
- To transform a natural product into a unique structural framework.
- To demonstrate the potential for generating diverse natural product-like compound libraries.
- To explore novel synthetic routes from natural product starting materials.
Main Methods:
- Utilized a ring-closing iodoalkoxylation reaction.
- Employed X-ray crystallography for structural confirmation.
- Synthesized a small series of derivatives.
Main Results:
- Transformed alkaloid haemanthamine into a novel intricate ring system.
- Generated a compound with a high number of stereocenters.
- Confirmed the new structure via X-ray analysis.
Conclusions:
- The developed method provides access to unique, complex molecular architectures.
- This approach facilitates the creation of diverse natural product-like compound collections.
- The novel framework holds potential for future drug discovery efforts.
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