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The Emerging Role of Tractography in Deep Brain Stimulation: Basic Principles and Current Applications
Nelson B Rodrigues1,2,3, Karim Mithani4,5, Ying Meng6,7,8
1Sunnybrook Research Institute, Toronto, ON M4N 3M5, Canada. nelson.rodrigues@mail.utoronto.ca.
Brain Sciences
|February 1, 2018
Summary
Diffusion tensor imaging (DTI) uses MRI to map brain white matter tracts via water diffusion tracking. Tractography aids neurosurgery, particularly in developing new deep brain stimulation targets.
Area of Science:
- Neuroimaging
- Neuroscience
- Neurosurgery
Background:
- Diffusion Tensor Imaging (DTI) is an MRI technique for visualizing brain white matter architecture.
- Tractography, derived from DTI, maps neural pathways by tracking water diffusion.
- This technique is crucial in clinical neuroscience for studying brain structure and disease.
Purpose of the Study:
- To review the fundamental principles of Diffusion Tensor Imaging.
- To discuss the current applications of tractography in functional neurosurgery.
- To explore the role of tractography in identifying and refining novel deep brain stimulation targets.
Main Methods:
- Overview of Diffusion Tensor Imaging (DTI) principles.
- Review of tractography methodologies.
- Analysis of existing literature on tractography in neurosurgical targeting.
Main Results:
- DTI and tractography provide detailed visualization of white matter tracts.
- Tractography is increasingly utilized for pre-surgical planning in functional neurosurgery.
- The application of tractography aids in the development of precise deep brain stimulation targets.
Conclusions:
- Diffusion Tensor Imaging and tractography are valuable tools in neuroscience and neurosurgery.
- Tractography enhances the precision of neurosurgical interventions, including deep brain stimulation.
- Continued research in tractography promises to advance functional neurosurgery and the treatment of neurological disorders.
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